New - The Metabolic Syndrome Program How to Lose Weight, Beat Heart Disease, Stop Insulin Resistance and More Big Belly? High Body Mass Index? High Blood Pressure? If this sounds like you, you may be one of the millions of North Americans with Metabolic Syndrome. Predicted by medical experts as the likely number one risk factor for heart disease-Metabolic Syndrome, or MSX, describes a constellation of conditions, including those mentioned above, of which the body' resistance to insulin is a p